Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid.

نویسندگان

  • Alex M Chen
  • Martha E Ellison
  • Andrey Peresypkin
  • Robert M Wenslow
  • Narayan Variankaval
  • Cecile G Savarin
  • Theresa K Natishan
  • David J Mathre
  • Peter G Dormer
  • Danielle H Euler
  • Richard G Ball
  • Zhixiong Ye
  • Yaling Wang
  • Ivan Santos
چکیده

We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.

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عنوان ژورنال:
  • Chemical communications

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2007